The primary importance of nutritional fats in lifestyle related diseases and conditions

Scientific studies show a clear relationship between diet, genetics and health. Many studies suggest that human beings evolved on a diet with a ratio of omega 3 to omega 6 essential fatty acids (EFA) of approximately 1:1. In the modern diet, the ratio has changed drastically. Modern diets are deficient in omega-3 fatty acids, and have excessive amounts of omega-6 fatty acids compared with the diet on which humans evolved and their genetic patterns were established.

The opposing effects of omega-3 and omega-6 fatty acids on human health are due to three molecular mechanisms: 1) they compete for the same set of enzymes to produce signalling molecules that have opposing physiological functions. While omega-3 derived signalling molecules are anti-inflammatory, omega-6 derived are pro inflammatory; 2) they compete for direct transcription factors binding to modulate the expression of different sets of target genes; and 3) they compete to incorporate into cell membranes, directly impacting the function of the cell.

The preventive role of nutritional fats in many lifestyle related diseases and conditions

Omega-3 and omega-6 fatty acids compete for the same enzymes to produce eicosanoids and DHA-derived decosanoids with opposing physiological functions. Many omega-3 and omega-6 fatty acids derived eicosanoids and docosanoids directly bind to nuclear hormone receptor transcription factors to modulate the target gene regulation. Omega-3 and omega-6 fatty acids also compete to incorporate into cell membranes, directly impacting the function of the cell. The opposing effects of omega-3 and omega-6 fatty acids lead to the omega-6 to omega-3 ratio so crucial in human growth, health and development. In those who are genetically predisposed to certain cancers, diabetes, heart disease etc. the importance of omega 3 and 6 ratio is greater considering its effect on transcription factors and keeping the omega 6 to omega 3 ratio low in their diet will delay or even prevent the occurrence.

A scientific knowledge of nutrition will provide the key to understanding many diseases and disorders

Most of the cooking oils currently available are having a high content of omega 6 fat and almost no omega 3 fat. Most of the nuts/ oil seeds like cashews, peanuts, badam, pista, sunflower seed, cotton seed etc. have a high omega 6 fat content and no omega 3 fat. Small amount of omega 3 linolenic acid in the cereals and pulses are usually lost during processing and in effect omega 6 content is very high and omega 3 content is almost nil or very low. When the omega 6 linoleic is in high concentration even the available little amount of omega 3 linolenic acid will not be converted to active derivatives of omega 3 due to competition for the enzyme from omega 6 linoleic acid.

The relation between the composition of nutrition and the composition of the body is reflected in the root cause of many disease conditions

It is ideal to have a diet with omega 3 and 6 fats in 1:1 ratio and it is the solution that the body asks for overcoming many health problems. There is no such food/ oil available in nature. Omega 3 fat has 3 or more unsaturated double bonds and omega 6 fat has 2 or more double bonds and are highly unstable and prone to oxidative damage in the shelf and after absorption into the body. The polyunsaturated fatty acid (PUFA)omega 3 and 6 and its metabolites with higher level of unsaturation called long chain polyunsaturated fat(LCPUFA) if taken without sufficient antioxidants to protect its double bonds can lead to oxidative cell damage. The high intake of PUFA without proportionally high quantity of antioxidant is detrimental to health due to possible oxidative damage to cell membranes.

Search for a practical solution to correct omega 3 and 6 fats in cooking /cosmetic oil which can resist oxidative damage in the shelf and inside the body lead to the development of optimized nutrient oil. The patent application was submitted in India in 2014 November and to WIPO (world intellectual property office) in 2015, published in 2016 as WO2016071927 A3 After receiving the international search report and preliminary examination report on patentability national entry application was submitted in 121 countries in 2017 covering all the major countries around the globe.

Salts in nutrition have a continuous impact on the body processes and their composition affects body composition which helps overcome many diseases and conditions

Evolutionally as a terrestrial animal, human kidney has the capacity to retain sodium and can live with as low as around 500 mg of sodium per day. But our capacity to retain potassium is low. Many studies show there is a deficiency in potassium intake and an excess intake of sodium in the modern diet. For optimal functioning of body sodium to potassium ratio in the diet and body should be around 1:3, but in modern diet it is showing a tendency for reversal of the ratio leading to lifestyle diseases like hypertension, cardiovascular diseases, stroke, urinary stone and osteoporosis.

To solve the problem of potassium deficiency and sodium excess in the diet and associated lifestyle disease challenges we need a salt composition which has a proportion of sodium and potassium 1:3 ratio. Search for an ideal salt composition resulted in the development of optimized nutrient salt. The patent application was submitted in India in 2017 February and to WIPO (World Intellectual Property Office) in 2018 January.

Cell Activation is an easy and simple methodology for lifestyle correction suited for the modern lifestyle aiming at stimulating each cell of the human body to function in the optimal way. Hippocrates observed, ‘If we could give every individual the right amount of nourishment and exercise, not too little and not too much, we would have found the safest way to health.’ The search for the safest method to ensure every individual receives the right amount of nourishment and exercise, not too little and not too much lead to the development of Cell Activation. It has three aspects. 1. Cell nutrition. 2. Cell stimulation. 3. Cell support.

Cell Activation is an easy and simple methodology for lifestyle correction suited for the modern lifestyle aiming at stimulating each cell of the human body to function in the optimal way. Hippocrates observed, ‘If we could give every individual the right amount of nourishment and exercise, not too little and not too much, we would have found the safest way to health.’ The search for the safest method to ensure every individual receives the right amount of nourishment and exercise, not too little and not too much lead to the development of Cell Activation. It has three aspects. 1. Cell nutrition. 2. Cell stimulation. 3. Cell support.

Optimised nutrition focuses on nutrition where only nutritional ingredients are present

“Hyper palatability is destroying health from infant food stage in most situations”

Scientific research and development in the field of nutrition, health, disease and treatment has identified and quantified requirement for each of the nutrients for humans at different stages of life. The modern high calorie, high omega 6 fat, high sodium, low fibre, low omega 3 fat, low potassium diet along with lack of supportive physical activity is the major causative factor of the DRNCD (Diet related non communicable diseases) / lifestyle diseases. A very dangerous trend is the presence of so called fillers which form the bulk of many processed food products which negatively affect the health of the consumers whether a child or an adult. Another important factor is the increasing level of toxins in the form of pesticides, weed killers, preservatives, colouring and flavouring agents in the modern day food.

An ideal food should contain all nutrients in the correct proportion and be devoid of any toxic content. There is no natural food in the world which meets all nutritional requirements of the human except breast milk up to the age of 6 months, provided mother gets adequate nutrition. Hippocrates said “Let food be your medicine and medicine be your food.”(2000 years ago). This advice is as valuable now as ever.

Maintaining daily activities

Mechanisation in all aspects of modern life has reduced physical activity and calorie requirement in day to day life. Excess calories in the diet will be stored as fat. The easy availability of high calorie processed food rich in sugar, starch and unhealthy fats leads to overweight and obesity. This overweight and obesity is the stepping stone towards an array of lifestyle diseases. Actually overweight and obesity are forms of malnutrition (improper nutrition).This malaise is no longer a disease of the developed world or rich society, it is drastically increasing among the poor in the developing world also.

Stimulating all body parts needed for maintaining body movements

Hippocrates noticed ‘That which is used – develops, that which is not used wastes away’. Regular stimulation of cells in the body is needed to keep the cells healthy in this sedentary lifestyle. An ideal stimulation protocol should result in stimulation of all the cells in the body without negatively stressing any part of the body.

Understanding how muscle activity produces varied products for maintaining health

There are around 600 muscles in our body. There is an emerging understanding of how skeletal muscles release myokines when they are activated. Muscles produce myokines which act as mediators of physical and mental fitness. Different muscle fibre types -slow twitch muscle fibres, oxidative muscle fibres, intermediate twitch muscle fibres, and fast twitch muscle fibres – release different clusters of myokines during contraction. Myostatin, LIF, IL-6 and IL-7 are involved in muscle hypertrophy and myogenesis, whereas BDNF and IL-6 are involved in AMPK-mediated fat oxidation.

Understanding how the action of muscles and chronic diseases are related

S IL-6 has systemic effects on the liver, adipose tissue and the immune system, and mediates crosstalk between intestinal L cells and pancreatic islets. Other myokines include osteogenic factors IGF-1 and FGF-2; FSTL-1, which improves endothelial function of the vascular system. Studies in the past few years suggest the existence of yet unidentified factors, secreted from muscle cells, which may influence cancer cell growth and pancreas function. Many proteins produced by skeletal muscle are dependent upon contraction; therefore, physical inactivity leads to an altered myokines response, which could provide a potential mechanism for the association between sedentary behaviour and many chronic diseases.

Understanding the relation between health condition and conventional exercises to prevent tissue damage

Most exercises we adopt currently like walking, swimming, cycling, and aerobics are usually stimulating only some parts excessively. This can lead to wear and tear of some parts of the body and some other parts may not be used at all. For example during walking buttocks and some muscles of lower limb get activated repeatedly. This excess use of some part alone can lead to long term problems like damaging the joints especially knee joints The damage can be more in obese due to the excess weight on the weight bearing joints. The vertebral and abdominal muscles will not get much exercise by walking. This lack of balanced activity is the major reason for growing abdominal obesity, back pain, neck problems and disk prolapse. Many become victims of lifelong painkilling drugs, balms or undergo surgeries which at best give temporary relief without removing the underlying cause.

The need for activity as a stimulator rather than as a stress creator for patients

The search for developing an easily adaptable pattern which follows the principles of total, moderate, practical (even for the lifestyle disorder patient) and stress reversing activity lead to the development of cell stimulation protocol. It is a series of breath controlled movements for improving circulation, oxygenation and removal of metabolic waste from the cells along with stimulation of all the cells of the body by gentle movement, massage, vibration and thought process. All parts of the body including internal organs and internal muscles are stimulated in a systematic, proportionate way as per the individual requirements. No part is stimulated to excess or too little in cell stimulation protocol.

The need to develop a stimulation pattern that focuses on applicability to individuals in varying physical conditions with a focus on healthy lean mass fat mass ratio

It is done in lying / sitting position on a comfortable soft mattress preferably on the bed. No special space or equipment is needed. After initial training no supervision is needed for regular practice. As it is done in lying/ sitting position it will not strain the leg/ knee and is suited for overweight/ obese, postoperative/ recuperating patients as it is individualized as per need.

External physical toxins that the body interacts are from the air we breathe, the foods we consume, products in physical contact and they have varying impacts on lifestyle diseases

Cell support includes cell protection and stress utilisation. Cell protection is made possible by reducing the avoidable functional burden on the cells physically and chemically. Our body is covered and protected from environmental factors externally by skin and internally by mucous membrane. Inside this physical barrier immune system has an array of defence mechanisms for protection from environmental factors. The range of lifestyle diseases has grown rapidly in recent years. Exposure to environmental pollution, chemical load, (products applied on the face, skin, hair and other daily use products ), increased radiation and the modern sedentary lifestyle easily break down the already weakened immune system.

Chronic stress can derail the body’s protective mechanism and toxins also play a major role in creating stress

Chronic stress (Negative stress) makes changes in neuroendocrine function leading to psychological disorders and immune system dysfunction. Optimal cell nutrition and cell stimulation improves the body’s ability to withstand stress. Stress relief can prevent stress related psychological disorders like depression, irritability and physical disorders like overeating and obesity which are the stepping stones towards an array of lifestyle diseases. Stress related neuroendocrine changes can lead to immune system dysfunction leading to lifestyle disorders like diabetes, hypertension, cancer etc. Stress relief has a major role in preventing lifestyle disorders. Specific stress utilisation,relief and relaxation methods are included in this Cell Support protocol.

Understanding the risks associated with products of daily use and being sensitive in their choice will help in avoiding many lifestyle diseases and conditions

Increase of human population, industrialization, fossil energy use and modern lifestyle has resulted in toxic load in the air we breathe and the water we drink. Atmospheric radiation hazard increases with ozone layer damage, atomic energy use and rampant wireless technology. Food additives for preservation, texture, colour and taste enhancement with low fibre put strain on intestinal microbes, digestive system and associated immune system. Perfumes, deodorants and smoke can damage the lung mucosa and associated immune cells. Cosmetics, hair and nail colour, body care products and cleansing agents all put the skin and associated immune system on added strain.

Many harmful chemicals get into our body without giving warning signs especially those in combinations masking taste and smell as food additives and ingredients and as cosmetics and body care products. Their long term use will harm the body especially the immune system leading to immune dysfunction like cancers, autoimmune diseases and excretory system damage leading to organ failure like kidney failure, liver failure and so on. We get sick when our immune system cannot handle the challenges successfully. This can take different forms like infections, allergies, cancer, inflammatory diseases like heart attack or autoimmune diseases like arthritis.

Support for cells is planned by identifying the personal risk factors after analysing the lifestyle to find the possible preventive measures. Lifestyle burden impact is highest on the skin cells. An ideal skin care product should contain only nutrients which nourish the skin and protects the cells from environmental factors.